The bark of Anogeissus latifolia (Roxb. ex DC.) Wall. ex Guill. and Perr. (Combretaceae) has been reported to be used in the treatment of various diseases like wound healing, antioxidant activity and skin disease. The anti-inflammatory activity of Hydroalcoholic extract of bark of Anogeissus latifolia was evaluated in rodents using acute and chronic inflammatory models in order to validate ethnobotanical claims regarding the plant use in the above mentioned diseases. Anti-inflammatory potential of Anogeissus latifolia extract (ALE) (200 and 400 mg/kg body weight) was studied in acetic acid induced vascular permeability, croton oil induced ear edema and increase capillary permeability in ear. Cotton pellet granuloma, antioxidant enzyme estimation (LPO, SOD, GSH, and Catalase) and determination of serum level IL-6 and TNF- α using enzyme linked immunosorbent assay. Antioxidant enzymes and IL-6 and TNF- α estimation were done in cotton pellet induced granuloma inflammatory model. The results of present study showed for the first time that ALE possesses anti-inflammatory activity by significant inhibition of increase vascular permeability, inhibition of ear edema and reduced weight of cotton pellet. ALE decreased LPO while concurrently increase SOD, GSH and Catalase level. ALE also decreases the level of IL-6 and TNF-α in serum of treated groups compare to control one. Hence present study demonstrated that A. Latifolia bark extract has a potent anti-inflammatory activity against different phases of inflammation.
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